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  1. Biophysics of Nucleic Acids Celebrating the 75th Birthday of Professor Kenneth J. Breslauer
    Contributor: Chalikian, Tigran (Herausgeber); Völker, Jens (Herausgeber)
    Published: 2023
    Publisher:  MDPI - Multidisciplinary Digital Publishing Institute, Basel

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    Source: Union catalogues
    Contributor: Chalikian, Tigran (Herausgeber); Völker, Jens (Herausgeber)
    Language: English
    Media type: Ebook
    Format: Online
    ISBN: 9783036560977
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    Subjects: Research & information: general; Biology, life sciences
    Other subjects: nucleic acid structures; nucleic acid conformation; biological structure database; DNA; RNA; validation standards; G-quadruplex; replication; thermodynamics; ligand; topology; quadruplex-duplex hybrids; minor groove binding drugs; stability; optical spectroscopy; nucleic acids; charge; electrostatic potential; ab initio methods; NMR spectroscopy; molecular dynamics; forcefield; AMBER; B-DNA; DNA-hairpin; perchlorates; brines; pressure; Mars; habitability; DNA minor groove binder; mixed base-pair DNA sequences; sequence selectivity; ligand-DNA complex thermodynamic; molecular curvature; heterocyclic diamidine; biosensor; calorimetry; DNA conjugate; metal ion; triple helix; silver ion; lanthanide; ATP sensor; aptamer; terpyridine; sequence edition; DNAzyme; molecular dynamics simulation (MD); potential of mean force (PMF); dsDNA-dsDNA interactions; flexibility; origins of life; DNA-protein networks; protocells; DNA sequence-dependent structure; DNA deformability; DNA sequence context; DNA curvature; DNA minicircles; hydrostatic pressure; volume; CD spectroscopy; G-quadruplexes; potassium; polymorphism; kinetics; folding; kinetic models; fitting; aurintricarboxylic acid (ATA); salicylic acid polymers; methylene-salicylic acid; SARS-CoV-2; RNA-dependent RNA polymerase (RdRp); yeast ribosomes; human serum albumin (HSA); molecular recognition; biological function and viral disease; inhibitor binding; single-molecule biophysics; nucleic acid thermodynamics; statistical mechanics; fluctuation theorems; computational biophysics; n/a; drug discovery; drug-target interactions; thermodynamic binding signatures; isothermal titration calorimetry; lead optimization; fragment-based drug discovery; drug-like properties; enthalpic efficiency; group efficiency; lipophilic efficiency
    Scope: 1 electronic resource (282 pages)
  2. Deconstruction Is/In America
    A New Sense of the Political
    Author: Haverkamp, Anselm; Dodge, H. R.
    Published: [1995]; © 1995
    Publisher:  New York University Press, New York, NY

    What impact has deconstruction had on the way we read American culture? And how is American culture itself peculiarly deconstructive? To address these questions, this volume brings together some of the most provocative thinkers associated with... more

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    What impact has deconstruction had on the way we read American culture? And how is American culture itself peculiarly deconstructive? To address these questions, this volume brings together some of the most provocative thinkers associated with deconstruction, among them Jacques Derrida, Judith Butler, and Avital Ronnel. Ranging across a wide field, from the ethics of reading to the rhetoric of performance, the contributors offer provocative insights into a new sense of the political. The America of the volume's title turns out to be the place where the politics and poetics of responsibility meet. It is also the place where we confront the tension between difference and profound otherness

     
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    Source: Staatsbibliothek zu Berlin
    Language: English
    Media type: Ebook
    Format: Online
    ISBN: 9780814744772
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    Subjects: American; This; What; address; associated; brings; culture; deconstruction; deconstructive; impact; important; itself; most; peculiarly; questions; read; some; these; thinkers; together; volume; with; POLITICAL SCIENCE / Essays; Criticism; Criticism; Deconstruction; Deconstruction
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    Description based on online resource; title from PDF title page (publisher's Web site, viewed 23. Jun 2020)
  3. Deconstruction Is/In America
    A New Sense of the Political
    Author: Haverkamp, Anselm; Dodge, H. R.
    Published: [1995]; © 1995
    Publisher:  New York University Press, New York, NY

    What impact has deconstruction had on the way we read American culture? And how is American culture itself peculiarly deconstructive? To address these questions, this volume brings together some of the most provocative thinkers associated with... more

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    What impact has deconstruction had on the way we read American culture? And how is American culture itself peculiarly deconstructive? To address these questions, this volume brings together some of the most provocative thinkers associated with deconstruction, among them Jacques Derrida, Judith Butler, and Avital Ronnel. Ranging across a wide field, from the ethics of reading to the rhetoric of performance, the contributors offer provocative insights into a new sense of the political. The America of the volume's title turns out to be the place where the politics and poetics of responsibility meet. It is also the place where we confront the tension between difference and profound otherness

     
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    Source: Union catalogues
    Language: English
    Media type: Ebook
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    ISBN: 9780814744772
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    Subjects: American; This; What; address; associated; brings; culture; deconstruction; deconstructive; impact; important; itself; most; peculiarly; questions; read; some; these; thinkers; together; volume; with; POLITICAL SCIENCE / Essays; Criticism; Criticism; Deconstruction; Deconstruction
    Scope: 1 online resource
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    Description based on online resource; title from PDF title page (publisher's Web site, viewed 23. Jun 2020)
  4. Biophysics of Nucleic Acids Celebrating the 75th Birthday of Professor Kenneth J. Breslauer
    Contributor: Chalikian, Tigran (Herausgeber); Völker, Jens (Herausgeber)
    Published: 2023
    Publisher:  MDPI - Multidisciplinary Digital Publishing Institute, Basel ; OAPEN FOUNDATION, The Hague

    This Special Issue comprises 15 papers broadly outlining current trends in nucleic acid biophysics. It contains original research papers and reviews on structure, stability, and interactions of canonical and non-canonical nucleic acids. The authors... more

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    This Special Issue comprises 15 papers broadly outlining current trends in nucleic acid biophysics. It contains original research papers and reviews on structure, stability, and interactions of canonical and non-canonical nucleic acids. The authors describe the use of established, time-honored experimental and computational techniques as well as their more recently developed counterparts. Molecular insights that can be gained from the papers collected in this issue range from the fundamental to the applied with emphasis on biological functions and biomedical prospects of nucleic acids. The collection is not meant to be exhaustive, but to highlight recent advances from select laboratories worldwide. Nevertheless, it represents a useful guide for scientists who wish to familiarize themselves with biophysical topics in nucleic acid research. This Special Issue will be useful both for researchers who study fundamental aspects of nucleic acid structure, stability, and dynamics, as well as for those that are mainly interested in practical biological and biomedical applications of nucleic acids.

     
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    Source: Union catalogues
    Contributor: Chalikian, Tigran (Herausgeber); Völker, Jens (Herausgeber)
    Language: English
    Media type: Ebook
    Format: Online
    ISBN: 9783036560977; 9783036560984
    Subjects: Research & information: general; Biology, life sciences
    Other subjects: nucleic acid structures; nucleic acid conformation; biological structure database; DNA; RNA; validation standards; G-quadruplex; replication; thermodynamics; ligand; topology; quadruplex-duplex hybrids; minor groove binding drugs; stability; optical spectroscopy; nucleic acids; charge; electrostatic potential; ab initio methods; NMR spectroscopy; molecular dynamics; forcefield; AMBER; B-DNA; DNA-hairpin; perchlorates; brines; pressure; Mars; habitability; DNA minor groove binder; mixed base-pair DNA sequences; sequence selectivity; ligand–DNA complex thermodynamic; molecular curvature; heterocyclic diamidine; biosensor; calorimetry; DNA conjugate; metal ion; triple helix; silver ion; lanthanide; ATP sensor; aptamer; terpyridine; sequence edition; DNAzyme; molecular dynamics simulation (MD); potential of mean force (PMF); dsDNA–dsDNA interactions; flexibility; origins of life; DNA-protein networks; protocells; DNA sequence-dependent structure; DNA deformability; DNA sequence context; DNA curvature; DNA minicircles; hydrostatic pressure; volume; CD spectroscopy; G-quadruplexes; potassium; polymorphism; kinetics; folding; kinetic models; fitting; aurintricarboxylic acid (ATA); salicylic acid polymers; methylene-salicylic acid; SARS-CoV-2; RNA-dependent RNA polymerase (RdRp); yeast ribosomes; human serum albumin (HSA); molecular recognition; biological function and viral disease; inhibitor binding; single-molecule biophysics; nucleic acid thermodynamics; statistical mechanics; fluctuation theorems; computational biophysics; n/a; drug discovery; drug-target interactions; thermodynamic binding signatures; isothermal titration calorimetry; lead optimization; fragment-based drug discovery; drug-like properties; enthalpic efficiency; group efficiency; lipophilic efficiency
    Scope: 1 Online-Ressource (282 p.)
  5. Can the greater fool theory explain bubbles?
    evidence from China
    Author: Zou, Xuan
    Published: [2018]
    Publisher:  Rutgers University, Department of Economics, New Brunswick, NJ

    Many have noticed the phenomenon that naive investors are attracted to the market as stock prices soar, yet few empirical studies have tested for this bubble phenomenon. This paper presents previously unused data on the aggregate number of newly... more

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    Many have noticed the phenomenon that naive investors are attracted to the market as stock prices soar, yet few empirical studies have tested for this bubble phenomenon. This paper presents previously unused data on the aggregate number of newly opened brokerage accounts in China and tests the role of new investors in bubble formation. I find that new investors, attracted by soaring stock prices and the intensive trading activities of others, drove the Chinese stock market bubbles in 2007 and 2015, supporting the Greater Fool theory of bubbles. The inexperienced and naive new investors appear more likely to be the "greater fools." Using the residual orthogonalization method, I build a data-driven structural model system, where shocks from the new accounts variable explain 40-55% of Chinese stock return variation.

     
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    Source: Union catalogues
    Language: English
    Media type: Book
    Format: Online
    Other identifier:
    hdl: 10419/200274
    Series: [Departmental working papers / Rutgers University, Department of Economics ; 201804]
    Subjects: bubble; individual investors; volume; Chinese stock market
    Scope: 1 Online-Ressource (circa 60 Seiten), Illustrationen
  6. Liquidity, volume, and volatility
    Author: Bogousslavsky, Vincent; Collin-Dufresne, Pierre
    Published: 2019
    Publisher:  Swiss Finance Institute, Geneva

    We examine the relation between liquidity, volume, and volatility using a comprehensive sample of U.S. stocks in the post-decimalization period. For large stocks, effective spread and volume are positively related in the time series even after... more

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    Helmut-Schmidt-Universität, Universität der Bundeswehr Hamburg, Universitätsbibliothek
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    ZBW - Leibniz-Informationszentrum Wirtschaft, Standort Kiel
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    We examine the relation between liquidity, volume, and volatility using a comprehensive sample of U.S. stocks in the post-decimalization period. For large stocks, effective spread and volume are positively related in the time series even after controlling for volatility, contrary to most theoretical predictions. This relation is mostly driven by the systematic component of volume. In contrast, for small stocks the evidence matches the predictions of standard adverse selection models. In line with a continuous-time inventory model, we show that the volatility of order imbalances can reconcile our puzzling finding with standard intuition. Order imbalance volatility is strongly associated with spreads both in the time series and cross-section. Evidence from alternative liquidity measures (price impact and depth), spread decomposition, and intraday patterns support our interpretation of order imbalance volatility as a measure of inventory risk. Furthermore, order imbalance volatility is priced in the cross-section of weekly returns

     
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    Series: Research paper series / Swiss Finance Institute ; no 19, 69
    Swiss Finance Institute Research Paper ; No. 19-69
    Other subjects: Array
    Scope: 1 Online-Ressource (circa 59 Seiten), Illustrationen
  7. Measuring China's stock market sentiment
    Author: Li, Jia; Chen, Yun; Shen, Yan; Wang, Jingyi; Huang, Zhuo
    Published: April 2019
    Publisher:  Economic Research Initiatives @ Duke (ERID), Durham, NC

    This paper develops textual sentiment measures for China's stock market by extracting the textual tone of 60 million messages posted on a major online investor forum in China from 2008 to 2018. We conduct sentiment extraction by using both... more

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    This paper develops textual sentiment measures for China's stock market by extracting the textual tone of 60 million messages posted on a major online investor forum in China from 2008 to 2018. We conduct sentiment extraction by using both conventional dictionary methods based on customized word lists and supervised machine-learning methods (support vector machine and convolutional neural network). The market-level textual sentiment index is constructed as the average of message-level sentiment scores, and the textual disagreement index is constructed as their dispersion. These textual measures allow us to test a range of predictions of classical behavioral asset-pricing models within a unified empirical setting. We find that textual sentiment can significantly predict market return, exhibiting a salient underreaction-overreaction pattern on a time scale of several months. This effect is more pronounced for small and growth stocks, and is stronger under higher investor attention and during more volatile periods. We also find that textual sentiment exerts a significant and asymmetric impact on future volatility. Finally, we show that trading volume will be higher when textual sentiment is unusually high or low and when there are more differences of opinion, as measured by our textual disagreement. Based on a massive textual dataset, our analysis provides support for the noise-trading theory and the limits-to-arbitrage argument, as well as predictions from limited-attention and disagreement models

     
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    Source: Union catalogues
    Language: English
    Media type: Book
    Format: Online
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    Series: ERID working paper ; number 285
    Subjects: disagreement; machine learning; noise trading; sentiment; textual analysis; volatility; volume
    Scope: 1 Online-Ressource (circa 67 Seiten), Illustrationen
  8. Intraday trading invariancein the E-mini S&P 500 futures market
    Author: Andersen, Torben; Bondarenko, Oleg; Kyle, Albert S.; Obižaeva, Anna
    Published: August 2020
    Publisher:  CEFIR, Moscow

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    Source: Union catalogues
    Language: English
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    Series: NES working paper series ; no. 272
    Subjects: market microstructure; invariance; high-frequency trad-ing; liquidity; volatility; volume; time series; intraday patterns
    Scope: 1 Online-Ressource (circa 51 Seiten), Illustrationen
  9. Industrial organization, order Internalization, and invariance
    Author: Bondarenko, Oleg; Obižaeva, Anna; Wang, Yajun
    Published: August 2020
    Publisher:  CEFIR, Moscow

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    Source: Union catalogues
    Language: English
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    Series: NES working paper series ; no. 274
    Subjects: invariance; agreement to disagree; market power; trade size; price impact; pricingaccuracy; volume; volatility; market microstructure; industrial organization
    Scope: 1 Online-Ressource (circa 27 Seiten)
  10. Impact of bulk trades on price discovery in equity market
    Author: Rajvanshi, Vivek
    Published: [2021]
    Publisher:  Indian Institute of Management Calcutta, Calcutta

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    Series: Working paper series / Indian Institute of Management Calcutta ; no. 863
    Subjects: Aktienmarkt; Wertpapierhandel; Institutioneller Investor; Börsenkurs; Manipulation; Indien; Front running; price manipulation; abnormal returns; volume; delivery; bulk deal
    Scope: 1 Online-Ressource (circa 33 Seiten)
  11. The dynamics of trading duration, volume and price volatility
    a vector MEM model
    Published: 2013
    Publisher:  Cardiff Univ, Cardiff Business School, Economics Section, Cardiff

    We propose a general form of vector Multiplicative Error Model (MEM) for the dynamics of duration, volume and price volatility. The vector MEM relaxes the two restrictions often imposed by previous empirical work in market microstructure research, by... more

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    We propose a general form of vector Multiplicative Error Model (MEM) for the dynamics of duration, volume and price volatility. The vector MEM relaxes the two restrictions often imposed by previous empirical work in market microstructure research, by allowing interdependence among the variables and relaxing weak exogeneity restrictions. We further propose a multivariate lognormal distribution for the vector MEM. The model is applied to the trade and quote data from the New York Stock Exchange (NYSE). The empirical results show that the vector MEM captures the dynamics of the trivariate system successfully. We find that times of greater activity or trades with larger size coincide with a higher number of informed traders present in the market. But we highlight that it is unexpected component of trading duration or trading volume that carry the information content. Moreover, our empirical results also suggest a significant feedback effect from price process to trading intensity, while the persistent quote changes and transient quote changes affect trading intensity in different direction, confirming Hasbrouck (1988,1991).

     
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    Source: Union catalogues
    Language: English
    Media type: Book
    Format: Online
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    hdl: 10419/101123
    Series: Cardiff economics working papers ; E2013/7
    Subjects: vector MEM; ACD; GARCH; intraday trading process; duration; volume; volatility
    Scope: Online-Ressource (40 S.), graph. Darst.
  12. Deconstruction Is/In America
    A New Sense of the Political
    Author: Haverkamp, Anselm; Dodge, H. R.
    Published: [1995]; ©1995
    Publisher:  New York University Press, New York, NY

    What impact has deconstruction had on the way we read American culture? And how is American culture itself peculiarly deconstructive? To address these questions, this volume brings together some of the most provocative thinkers associated with... more

     

    What impact has deconstruction had on the way we read American culture? And how is American culture itself peculiarly deconstructive? To address these questions, this volume brings together some of the most provocative thinkers associated with deconstruction, among them Jacques Derrida, Judith Butler, and Avital Ronnel. Ranging across a wide field, from the ethics of reading to the rhetoric of performance, the contributors offer provocative insights into a new sense of the political. The America of the volume's title turns out to be the place where the politics and poetics of responsibility meet. It is also the place where we confront the tension between difference and profound otherness

     
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    Source: Union catalogues
    Language: English
    Media type: Ebook
    Format: Online
    ISBN: 9780814744772
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    Subjects: POLITICAL SCIENCE / Essays
    Other subjects: American; This; What; address; associated; brings; culture; deconstruction; deconstructive; impact; important; itself; most; peculiarly; questions; read; some; these; thinkers; together; volume; with
    Scope: 1 Online-Ressource
  13. Selective-referral and unobserved patient heterogeneity
    bias in the volume-outcome relationship
    Author: Hentschker, Corinna; Mennicken, Roman
    Published: 2014
    Publisher:  RWI, Essen

    This paper examines the causal effect of the experience of a hospital with treating hip fractures (volume) on treatment outcome for patients. A full sample of administrative data from Germany for the year 2007 is used. We apply an instrumental... more

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    Niedersächsische Staats- und Universitätsbibliothek Göttingen
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    Staats- und Universitätsbibliothek Hamburg Carl von Ossietzky
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    ZBW - Leibniz-Informationszentrum Wirtschaft, Standort Kiel
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    This paper examines the causal effect of the experience of a hospital with treating hip fractures (volume) on treatment outcome for patients. A full sample of administrative data from Germany for the year 2007 is used. We apply an instrumental variable approach to eliminate endogeneity concerns due to reverse causality and unobserved patient heterogeneity. As instruments for case volume we use the number of potential patients and the number of further hospitals in the region around every hospital. Our results indicate that after application of an IV regression of volume on outcome, volume significantly increases quality. Dieser Beitrag analysiert den kausalen Effekt zwischen der Zahl der Fälle eines Krankenhauses und der Qualität der Behandlung für Patienten mit einer Hüftfraktur. Es werden administrative Daten aus Deutschland für das Jahr 2007 genutzt. Wir führen eine Instrumentenvariablenschätzung durch, um Endogenitätsprobleme durch umgekehrte Kausalität sowie durch ausgelassene Variablen zu eliminieren. Als Instrumente nutzen wir die Anzahl potenzieller Patienten sowie die Anzahl weiterer Krankenhäuser in der Umgebung von jedem Krankenhausstandort. Unsere Ergebnisse zeigen, dass die Fallzahl einen signifikanten Effekt auf die Behandlungsqualität hat und damit als eine Einflussgröße betrachtet werden kann, die die Qualität erhöht.

     
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    Source: Union catalogues
    Language: English
    Media type: Ebook
    Format: Online
    ISBN: 9783867886024
    Other identifier:
    hdl: 10419/104736
    Series: Ruhr economic papers ; 527
    Subjects: volume; hospital quality; mortality; instrumental variables
    Scope: Online-Ressource (25 S.)
    Notes:

    Zsfassung in dt. Sprache
  14. Selective-referral and unobserved patient heterogeneity
    bias in the volume-outcome relationship ; conference paper
    Author: Hentschker, Corinna; Mennicken, Roman
    Published: 2014
    Publisher:  ZBW, [Kiel

    This paper examines the causal effect of volume on outcome on the example of patients with a hip fracture. We use an instrumental variable approach and consider both the practice-makes-perfect and selective-referral hypothesis as well as unobserved... more

    Location:
    ZBW - Leibniz-Informationszentrum Wirtschaft, Standort Kiel
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    DSM 13
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    No inter-library loan

     

    This paper examines the causal effect of volume on outcome on the example of patients with a hip fracture. We use an instrumental variable approach and consider both the practice-makes-perfect and selective-referral hypothesis as well as unobserved patient heterogeneity. Our results indicate that unobserved severity drives the results in the volume-outcome relationship for hip fracture patients and with this the practice-makes-perfect hypothesis has an even stronger effect on hospital quality than expected so far.

     
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    Source: Union catalogues
    Language: English
    Media type: Book
    Format: Online
    Other identifier:
    hdl: 10419/100299
    Edition: Preliminary
    Series: Array ; V2
    Subjects: volume; hospital quality; mortality; instrumental variables
    Scope: Online-Ressource (25 S.)