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  1. Biophysics of Nucleic Acids Celebrating the 75th Birthday of Professor Kenneth J. Breslauer
    Contributor: Chalikian, Tigran (Herausgeber); Völker, Jens (Herausgeber)
    Published: 2023
    Publisher:  MDPI - Multidisciplinary Digital Publishing Institute, Basel

    Hochschulbibliothek der Fachhochschule Aachen
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    Source: Union catalogues
    Contributor: Chalikian, Tigran (Herausgeber); Völker, Jens (Herausgeber)
    Language: English
    Media type: Ebook
    Format: Online
    ISBN: 9783036560977
    Other identifier:
    Subjects: Research & information: general; Biology, life sciences
    Other subjects: nucleic acid structures; nucleic acid conformation; biological structure database; DNA; RNA; validation standards; G-quadruplex; replication; thermodynamics; ligand; topology; quadruplex-duplex hybrids; minor groove binding drugs; stability; optical spectroscopy; nucleic acids; charge; electrostatic potential; ab initio methods; NMR spectroscopy; molecular dynamics; forcefield; AMBER; B-DNA; DNA-hairpin; perchlorates; brines; pressure; Mars; habitability; DNA minor groove binder; mixed base-pair DNA sequences; sequence selectivity; ligand-DNA complex thermodynamic; molecular curvature; heterocyclic diamidine; biosensor; calorimetry; DNA conjugate; metal ion; triple helix; silver ion; lanthanide; ATP sensor; aptamer; terpyridine; sequence edition; DNAzyme; molecular dynamics simulation (MD); potential of mean force (PMF); dsDNA-dsDNA interactions; flexibility; origins of life; DNA-protein networks; protocells; DNA sequence-dependent structure; DNA deformability; DNA sequence context; DNA curvature; DNA minicircles; hydrostatic pressure; volume; CD spectroscopy; G-quadruplexes; potassium; polymorphism; kinetics; folding; kinetic models; fitting; aurintricarboxylic acid (ATA); salicylic acid polymers; methylene-salicylic acid; SARS-CoV-2; RNA-dependent RNA polymerase (RdRp); yeast ribosomes; human serum albumin (HSA); molecular recognition; biological function and viral disease; inhibitor binding; single-molecule biophysics; nucleic acid thermodynamics; statistical mechanics; fluctuation theorems; computational biophysics; n/a; drug discovery; drug-target interactions; thermodynamic binding signatures; isothermal titration calorimetry; lead optimization; fragment-based drug discovery; drug-like properties; enthalpic efficiency; group efficiency; lipophilic efficiency
    Scope: 1 electronic resource (282 pages)
  2. Biophysics of Nucleic Acids Celebrating the 75th Birthday of Professor Kenneth J. Breslauer
    Contributor: Chalikian, Tigran (Herausgeber); Völker, Jens (Herausgeber)
    Published: 2023
    Publisher:  MDPI - Multidisciplinary Digital Publishing Institute, Basel ; OAPEN FOUNDATION, The Hague

    This Special Issue comprises 15 papers broadly outlining current trends in nucleic acid biophysics. It contains original research papers and reviews on structure, stability, and interactions of canonical and non-canonical nucleic acids. The authors... more

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    Bibliothek der Hochschule Darmstadt, Zentralbibliothek
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    TU Darmstadt, Universitäts- und Landesbibliothek - Stadtmitte
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    Bibliothek der Frankfurt University of Applied Sciences
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    This Special Issue comprises 15 papers broadly outlining current trends in nucleic acid biophysics. It contains original research papers and reviews on structure, stability, and interactions of canonical and non-canonical nucleic acids. The authors describe the use of established, time-honored experimental and computational techniques as well as their more recently developed counterparts. Molecular insights that can be gained from the papers collected in this issue range from the fundamental to the applied with emphasis on biological functions and biomedical prospects of nucleic acids. The collection is not meant to be exhaustive, but to highlight recent advances from select laboratories worldwide. Nevertheless, it represents a useful guide for scientists who wish to familiarize themselves with biophysical topics in nucleic acid research. This Special Issue will be useful both for researchers who study fundamental aspects of nucleic acid structure, stability, and dynamics, as well as for those that are mainly interested in practical biological and biomedical applications of nucleic acids.

     

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    Source: Union catalogues
    Contributor: Chalikian, Tigran (Herausgeber); Völker, Jens (Herausgeber)
    Language: English
    Media type: Ebook
    Format: Online
    ISBN: 9783036560977; 9783036560984
    Subjects: Research & information: general; Biology, life sciences
    Other subjects: nucleic acid structures; nucleic acid conformation; biological structure database; DNA; RNA; validation standards; G-quadruplex; replication; thermodynamics; ligand; topology; quadruplex-duplex hybrids; minor groove binding drugs; stability; optical spectroscopy; nucleic acids; charge; electrostatic potential; ab initio methods; NMR spectroscopy; molecular dynamics; forcefield; AMBER; B-DNA; DNA-hairpin; perchlorates; brines; pressure; Mars; habitability; DNA minor groove binder; mixed base-pair DNA sequences; sequence selectivity; ligand–DNA complex thermodynamic; molecular curvature; heterocyclic diamidine; biosensor; calorimetry; DNA conjugate; metal ion; triple helix; silver ion; lanthanide; ATP sensor; aptamer; terpyridine; sequence edition; DNAzyme; molecular dynamics simulation (MD); potential of mean force (PMF); dsDNA–dsDNA interactions; flexibility; origins of life; DNA-protein networks; protocells; DNA sequence-dependent structure; DNA deformability; DNA sequence context; DNA curvature; DNA minicircles; hydrostatic pressure; volume; CD spectroscopy; G-quadruplexes; potassium; polymorphism; kinetics; folding; kinetic models; fitting; aurintricarboxylic acid (ATA); salicylic acid polymers; methylene-salicylic acid; SARS-CoV-2; RNA-dependent RNA polymerase (RdRp); yeast ribosomes; human serum albumin (HSA); molecular recognition; biological function and viral disease; inhibitor binding; single-molecule biophysics; nucleic acid thermodynamics; statistical mechanics; fluctuation theorems; computational biophysics; n/a; drug discovery; drug-target interactions; thermodynamic binding signatures; isothermal titration calorimetry; lead optimization; fragment-based drug discovery; drug-like properties; enthalpic efficiency; group efficiency; lipophilic efficiency
    Scope: 1 Online-Ressource (282 p.)
  3. The emigration life cycle: how development shapes emigration from poor countries
    Published: August 2020
    Publisher:  IZA - Institute of Labor Economics, Bonn, Germany

    Many governments seek to reduce emigration from low-income countries by encouraging economic development there. A large literature, however, observes that average emigration rates are higher in countries with sustained increases in GDP per capita... more

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    Verlag (kostenfrei)
    Resolving-System (kostenfrei)
    ZBW - Leibniz-Informationszentrum Wirtschaft, Standort Kiel
    DS 4
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    Many governments seek to reduce emigration from low-income countries by encouraging economic development there. A large literature, however, observes that average emigration rates are higher in countries with sustained increases in GDP per capita than in either chronically poor countries or established rich countries. This suggests an emigration life cycle in which average emigration first rises, then falls with development. But this hypothesis has not been tested with global datasets controlling for unobserved heterogeneity between countries. This paper finds that emigration rises on average as GDP per capita initially rises in poor countries, slowing after roughly US$5,000 at purchasing power parity, and reversing after roughly $10,000. Before this reversal, the within-country elasticity of rising emigration prevalence to rising GDP per capita is +0.35 to all destinations, and +0.74 to rich destinations. This relationship between emigration flows and economic growth is highly robust to country and time effects (fixed or random), specification (linear, log, nonparametric), emigration measure (stock or flow), country subsamples (rich destinations, large origins), and historical period (1960-2019 or 1850-1914). Decomposition of channels for this relationship highlight the joint importance of demographic transition, education investment, and structural change, but question a large role for transportation costs or policy barriers.

     

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    Source: Union catalogues
    Language: English
    Media type: Book
    Format: Online
    Other identifier:
    hdl: 10419/224056
    Series: Discussion paper series / IZA ; no. 13614
    Subjects: migration; development; hump; inverse-u; mobility; transition; pressure; poverty; immigration; emigration; demand; growth; pportunity; employment
    Scope: 1 Online-Ressource (circa 67 Seiten), Illustrationen
  4. Pathways for labor migration from Northern Central America
    five difficult but necessary proposals
    Published: October 2022
    Publisher:  IZA - Institute of Labor Economics, Bonn, Germany

    Very few labor-based pathways for regular migration are available for people in Northern Central America, often called the 'Northern Triangle' of Guatemala, Honduras, and El Salvador. This note briefly summarizes the state of labor-based migration... more

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    Verlag (kostenfrei)
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    ZBW - Leibniz-Informationszentrum Wirtschaft, Standort Kiel
    DS 443
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    Very few labor-based pathways for regular migration are available for people in Northern Central America, often called the 'Northern Triangle' of Guatemala, Honduras, and El Salvador. This note briefly summarizes the state of labor-based migration channels in the region. It then argues that extending those channels is a necessary complement to asylum reform even for the goal of humanitarian protection. It concludes by arguing that five recommendations for long-term reform, though difficult, are needed to unleash the maximum shared benefit of these pathways.

     

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    Source: Union catalogues
    Language: English
    Media type: Book
    Format: Online
    Other identifier:
    hdl: 10419/273704
    Series: IZA policy paper ; no. 195
    Subjects: migration; migrant; immigrant; irregular; illegal; unauthorized; undocumented; pressure; development; restrictions; visa; regulation; border; crisis; channels; smugglers; clandestine; Central America; Latin Americastine
    Scope: 1 Online-Ressource (circa 14 Seiten)
  5. Asymmetry of information within family networks
    Published: 2014
    Publisher:  IZA, Bonn

    This paper studies asymmetry of information and transfers within a unique data set of 712 extended family networks from Tanzania. Using cross-reports on asset holdings, we construct measures of misperception of income among all pairs of households... more

    ZBW - Leibniz-Informationszentrum Wirtschaft, Standort Kiel
    DS 4 (8395)
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    This paper studies asymmetry of information and transfers within a unique data set of 712 extended family networks from Tanzania. Using cross-reports on asset holdings, we construct measures of misperception of income among all pairs of households belonging to the same network. We show that there is significant asymmetry of information and no evidence of major systematic over-evaluation or under-evaluation of income in our data, although there is a slight over-evaluation on the part of migrants regarding non-migrants. We develop a static model of asymmetric information that contrasts altruism, pressure and exchange as motives to transfer. The model makes predictions about the correlations between misperceptions and transfers under these competing explanations. Testing these predictions in the data gives support to the model of transfers under pressure or an exchange motive with the recipient holding all the bargaining power.

     

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    Content information
    Source: Union catalogues
    Language: English
    Media type: Book
    Format: Online
    Other identifier:
    hdl: 10419/101807
    Series: Discussion paper series / Forschungsinstitut zur Zukunft der Arbeit ; 8395
    Subjects: Familie; Einkommen; Asymmetrische Information; Intergenerationale Übertragung; Tansania; asymmetric information; transfers; pressure; exchange; altruism
    Scope: Online-Ressource (52 S.), graph. Darst.
  6. Does development reduce migration?
    Published: 2014
    Publisher:  IZA, Bonn

    The most basic economic theory suggests that rising incomes in developing countries will deter emigration from those countries, an idea that captivates policymakers in international aid and trade diplomacy. A lengthy literature and recent data... more

    ZBW - Leibniz-Informationszentrum Wirtschaft, Standort Kiel
    DS 4 (8592)
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    The most basic economic theory suggests that rising incomes in developing countries will deter emigration from those countries, an idea that captivates policymakers in international aid and trade diplomacy. A lengthy literature and recent data suggest something quite different: that over the course of a "mobility transition", emigration generally rises with economic development until countries reach upper-middle income, and only thereafter falls. This note quantifies the shape of the mobility transition in every decade since 1960. It then briefly surveys 45 years of research, which has yielded six classes of theory to explain the mobility transition and numerous tests of its existence and characteristics in both macro- and micro-level data. The note concludes by suggesting five questions that require further study.

     

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    Source: Union catalogues
    Language: English
    Media type: Book
    Format: Online
    Other identifier:
    hdl: 10419/106535
    Series: Discussion paper series / Forschungsinstitut zur Zukunft der Arbeit ; 8592
    Subjects: migration; mobility; development; growth; transition; hump; lifecycle; inequality; poverty; aid; emigration; demand; pressure
    Scope: Online-Ressource (38, 5 S.), graph. Darst.